betamethasone dipropionate; betamethasone valerate (Celestone, Soluspan, Betasone)
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Introduction
Systemic agent: Tradename Celestone.
Indications
- skin disorders[4]
- seborrheic dermatitis, atopic dermatitis, neurodermatitis
- urticaria
- anogenital pruritus
- psoriasis
- inflammatory phase of xerosis
- late phase of allergic dermatitis or irritant dermatitis
- cutaneous T-cell lymphoma
- discoid lupus
- granuloma annulare
- respiratory[4]
- bronchopulmonary dysplasia
- laryngeal edema
- respiratory distress syndrome
- bronchitis
- COPD
- Loeffler's syndrome
- masal polyp
- fetal lung maturation
- neurologic[4]
- hematologic[4]
- oncology[4]
- rheumatology[4]
- endocrine[4]
- GI[4]
- renal[4]
- organ transplantation rejection[4]
- inflammatory effects of infections[4]
- berylliosis
- inflammatory eye disease
- procedures
Dosage
- 0.5-9.0 mg IM/PO QD
- 12 mg IM QD x 2 doses (fetal lung maturation) Tabs: 0.6 mg Liquid: 0.6 mg/5 mL. Injection: 6 mg/mL, 5 mL vials.
also see topical betamethasone
Adverse effects
- common (> 10%)
- temporary mild blurred vision
- increased appetite
- indigestion
- insomnia
- less common (1-10%)
- uncommon (< 1%)
- hypertrichosis, acne, perioral dermatitis, maceration of skin, skin atrophy, striae, miliaria, hypertension, sudden blindness, convulsions, vertigo, confusion, headache, thin fragile skin, sterile abscess, hyperpigmentation, hypopigmentation, Cushingoid state, peptic ulcer, itching, muscle weakness, osteoporosis, glaucoma, sodium retention, impaired wound healing
- miminal long-term (30 year) metabolic effects with antenatal exposure[3]
Drug interactions
- aminoglutethimide
- anticholinesterases
- barbiturates
- carbamazepine
- phenytoin
- rifampin
- live virus vaccines
- drug interaction(s) of methotrexate with biological response modifier
- drug interaction(s) of glucocorticoids with warfarin
- drug interaction(s) of NSAIDs with glucocorticoid
More general terms
More specific terms
Component of
- betamethasone/sodium phosphate
- betamethasone/isopropanol/lidocaine/povidone iodine
- betamethasone/bupivacaine/isopropanol/povidone iodine
- betamethasone/gentamicin/isopropanol
- betamethasone/gentamicin
- betamethasone/clotrimazole/gentamicin
- betamethasone/calcipotriene (Enstilar)
- betamethasone/clotrimazole (Lotrisone)
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ 3.0 3.1 Journal Watch 25(14):110, 2005 Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet. 2005 May 28;365(9474):1856-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15924982 [PubMed - in process]
Dalziel SR, Liang A, Parag V, Rodgers A, Harding JE. Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial. Pediatrics. 2004 Sep;114(3):e373-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15342900 - ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 Deprecated Reference