betamethasone dipropionate; betamethasone valerate (Celestone, Soluspan, Betasone)

Introduction

Systemic agent: Tradename Celestone.

Indications

• skin disorders
  • seborrheic dermatitis, atopic dermatitis, neurodermatitis
  • urticaria
  • anogenital pruritus
  • psoriasis
  • inflammatory phase of xerosis
  • late phase of allergic dermatitis or irritant dermatitis
  • cutaneous T-cell lymphoma
  • discoid lupus
  • granuloma annulare
• respiratory
  • bronchopulmonary dysplasia
  • laryngeal edema
  • respiratory distress syndrome
  • bronchitis
  • COPD
  • Loeffler's syndrome
  • masal polyp
  • fetal lung maturation
• neurologic
  • cerebral edema
  • multiple sclerosis
• hematologic
  • blood transfusion reaction
  • Diamond-Blackfan syndrome
  • autoimmune hemolytic anemia
  • immune thrombocytopenic purpura
  • thrombocytopenia
  • angioneurotic edema
• oncology
  • Hodgkin's disease
  • non-Hodgkin's lymmphoma
    • follicular lymphoma
  • Mycosis fungoides
  • multiple myeloma
  • acute lymphoblastic leukemia
• rheumatology
  • autoimmune disease
    • systemic lupus erythematosus
  • sarcoidosis
  • serum sickness
  • rheumatic fever, rheumatic heart disease, carditis
  • muscle spasm
  • bursitis
• endocrine
  • congenital adrenal hyperplasia
    • adrenogenital syndrome
  • adrenal insufficiency
  • hypercalcemia
• GI
  • celiac sprue
  • hepatic necrosis
• renal
  • nephrotic syndrome
• organ transplantation rejection
• inflammatory effects of infections
  • trichinosis
  • tuberculosis
• berylliosis
• inflammatory eye disease
• procedures
  • dexamethasone suppression test

Dosage

• 0.5-9.0 mg IM/PO QD
• 12 mg IM QD x 2 doses (fetal lung maturation) Tabs: 0.6 mg Liquid: 0.6 mg/5 mL. Injection: 6 mg/mL, 5 mL vials.

also see topical betamethasone

Adverse effects

• common (> 10%)
  • temporary mild blurred vision
  • increased appetite
  • indigestion
  • insomnia
• less common (1-10%)
  • itching, burning, erythema, dryness, irritation, papular rashes, burning of eyes, burning of ears, cataracts, diabetes mellitus
• uncommon (< 1%)
  • hypertrichosis, acne, perioral dermatitis, maceration of skin, skin atrophy, striae, miliaria, hypertension, sudden blindness, convulsions, vertigo, confusion, headache, thin fragile skin, sterile abscess, hyperpigmentation, hypopigmentation, Cushingoid state, peptic ulcer, itching, muscle weakness, osteoporosis, glaucoma, sodium retention, impaired wound healing
• miminal long-term (30 year) metabolic effects with antenatal exposure

• drug adverse effects of glucocorticoids
• drug adverse effects of immunosuppressive agents

Drug interactions

• aminoglutethimide
• anticholinesterases
• barbiturates
• carbamazepine
• phenytoin
• rifampin
• live virus vaccines

• drug interaction(s) of methotrexate with biological response modifier
• drug interaction(s) of glucocorticoids with warfarin
• drug interaction(s) of NSAIDs with glucocorticoid

More general terms

• glucocorticoid
• antipruritic agent

More specific terms

• Betamethasone Topical (Betatrex, Diprolene, Diprosone, Luxig foam, Valisone)

Component of

• all trans retinoic acid/betamethasone/hydroquinone
• betamethasone/gentamicin/isopropanol
• betamethasone/gentamicin
• betamethasone/clotrimazole/gentamicin
• betamethasone/calcipotriene (Enstilar)
• betamethasone/clotrimazole (Lotrisone)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9782