bronchopulmonary dysplasia
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Introduction
chronic lung disease of babies
Pathology
- environmental injury (hypothesis)
Clinical manifestations
- develops most commonly in the first 4 weeks after birth
- mostly occurs in babies who are born more than 4 weeks before their due dates
- sometimes the babies are full term
- babies have trouble breathing
Management
- supplmental oxygen
- mechanical ventilation may be necessary
- high-dose dexamethasone (0.5 mg/kg daily) to prevent or treat bronchopulmonary dysplasia in preterm infants of no benefit & may be harmful[1]
- inhaled budesonide for prevention in preterm infants
- does not prevent neurodevelopmental disability[3]
- increases mortality[3]
- inhaled budesonide for prevention in preterm infants
- enteral supplementation with docosahexaenoic acid does not improve respiratory outcomes (bronchopulmonary dysplasia) for extremely premature infants[2]
- prognosis
- most babies live
- in severe cases, a baby may die
More general terms
References
- ↑ 1.0 1.1 Choosing Wisely American Academy of Pediatrics Ten Things Physicians and Patients Should Question. http://www.choosingwisely.org/doctor-patient-lists/american-academy-of-pediatrics/
- ↑ 2.0 2.1 Collins CT et al. Docosahexaenoic acid and bronchopulmonary dysplasia in preterm infants. N Engl J Med 2017 Mar 30; 376:1245 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28355511 <Internet> http://www.nejm.org/doi/10.1056/NEJMoa1611942
- ↑ 3.0 3.1 3.2 Bassler D, Shinwell ES, Hallman M et al Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia. N Engl J Med 2018; 378:148-157. January 11, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29320647 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1708831
- ↑ What Is Bronchopulmonary Dysplasia ? http://www.nhlbi.nih.gov/health/dci/Diseases/Bpd/Bpd_WhatIs.html