Desonide Topical (DesOwen, Tridesilon)

Introduction

Non-fluorinated topical glucocorticoid.

Indications

• adjunctive therapy for inflammation & pruritus in acute & chronic, glucocorticoid-responsive dermatoses
  • seborrheic dermatitis
  • allergic dermatitis, atopic dermatitis, contact dermatitis
  • discoid lupus
  • granuloma annulare
  • psoriasis
  • lichen simplex chronicus
• cutaneous T-cell lymphoma

Contraindications

• do not use on eyelid

Dosage

Topical: apply BID-QID

Cream: 0.05% (15g, 30 g, 60g)

Ointment: 0.05% (15g, 60g)

Adverse effects

• uncommon (< 1%)
  • burning, itching, irritation, dryness, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae, miliaria

• drug adverse effects of glucocorticoids
• drug adverse effects of topical glucocorticoids
• drug adverse effects of immunosuppressive agents

Mechanism of action

• anti-inflammatory; topical glucocorticoid class 5

More general terms

• desonide; prednacinolone
• topical glucocorticoid (topical steroid)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12536
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=578798