anticholinergic toxicity
Jump to navigation
Jump to search
Introduction
also see anticholinergic agent
Clinical manifestations
- average onset < 12 hours
- confusion, delirium, agitation
- flushing
- anhidrosis
- mydriasis
- hallucinations
- hyperthermia, < 102.2 F (39 C)[2]
- tachypnea & tachycardia common
- hypertension[2]
- hypoactive bowel sounds
- reflexes, muscle tone normal
Management
- physostigmine
- if source known
- do not use if source unknown
- specifically contraindicated with tricyclic antidepressants
More general terms
Additional terms
References
- ↑ NEJM Knowledge+ Question of the Week. June 5, 2018 https://knowledgeplus.nejm.org/question-of-week/1826/
- ↑ 2.0 2.1 2.2 Sinert RH Fast Five Quis: Serotonin Syndrome Medscape. 2121. June 4. https://reference.medscape.com/viewarticle/951841
Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15784664 Review https://www.nejm.org/doi/10.1056/NEJMra041867