FK506-binding protein 1A (12 kD FK506-binding protein, immunophilin FKBP12, FKBP1A)

Function

• may play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the Ca+2 release channel of skeletal muscle sarcoplasmic reticulum
• there are 4 molecules of FKBP12 per skeletal muscle RYR.
• PPIases accelerate the folding of proteins
• catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
• inhibited by both FK506 & rapamycin

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the FKBP-type PPIase family, FKBP1 subfamily
• contains 1 PPIase FKBP-type domain

Compartment

cytoplasm

More general terms

• FK506 binding protein (FKBP)

Additional terms

• FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1; rapamycin target protein; RAPT1; mammalian target of rapamycin; mTOR (FRAP1, FRAP, FRAP2)

Database

• UniProt: http://www.uniprot.org/uniprot/P62942.html
• OMIM: https://mirror.omim.org/entry/186945