antiretroviral protease inhibitor

Introduction

Class of pharmceutical agents used for treatment of AIDS/HIV

Dosage

• almost always administered with ritonavir

Adverse effects

• hyperlipidemia:
  • increased cholesterol & triglycerides
  • protease inhibitor lipodystrophy
• hyperglycemia
• osteoporosis
• hyperprolactinemia

• drug adverse effects of antiretroviral protease inhibitors
• drug adverse effects of antiretroviral agents

Drug interactions

• HMG CoA reductase inhibitors
  • lovastatin & simvastatin metabolism may be slowed by protease inhibitors
  • pravastatin (Pravachol) or atorvastatin (Lipitor) are recommended for patients taking antiretroviral protease inhibitors
• nicotinic acid (niacin): additive effect on insulin-resistance & hyperglycemia
• ritonavir increases antiretroviral protease inhibitor levels
  • interaction used for therapeutic effect
• antiretroviral protease inhibitors metabolized by cyt P450 3A4 (saquinavir ...) may increase in plasma when coadministered with inhibitorss of cyt P450 3A4 (diatiazem, verapamil ...)

• drug interaction(s) of fluticasone with HIV1 protease inhibitors
• drug interaction(s) of antiretroviral protease inhibitor in combination with ritonavir
• drug interaction(s) of statins with antiviral protease inhibitors
• drug interaction(s) of antibiotics with warfarin

More general terms

• antiretroviral agent
• antiviral protease inhibitor

More specific terms

• amprenavir (Agenerase)
• atazanavir (Reyataz, ATV/r)
• darunavir (Prezista, DRV/r)
• fosamprenavir (Lexiva)
• indinavir (Crixivan)
• lopinavir (Aluviran)
• nelfinavir (Viracept)
• ritonavir (Norvir, RTV)
• saquinavir (Invirase, Fortovase)
• tipranavir (Aptivus, TPV)

Additional terms

• Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)
• HIV1 protease inhibitor lipodystrophy
• human immunodeficiency virus (HIV)