FK506-binding protein 10 (65 kD FK506-binding protein, immunophilin FKBP65, FKBP10)

Function

• PPIases accelerate the folding of proteins during protein synthesis
• inhibited by both FK506 & rapamycin, but not by cyclosporin A (putative)
• glycosylated & phosphorylated (putative)

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• contains 2 EF-hand domains
• contains 4 PPIase FKBP-type domains

Compartment

endoplasmic reticulum lumen (putative)

More general terms

• FK506 binding protein (FKBP)

Database

• OMIM: https://mirror.omim.org/entry/607063
• UniProt: http://www.uniprot.org/uniprot/Q96AY3.html