BK polyomavirus
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Epidemiology
- isolated from the urine of a renal transplant patients
- infection is common; antibodies to BK virus are present in 73% of children
Pathology
- causes BK virus-associated tubulointerstial nephropathy in renal transplant patients on immunosuppressants:[3]
Clinical manifestations
- infection occurs > 12 months after renal transplantation &/or intensive immunosuppression
Laboratory
- BK polyomavirus serology
- BK polyomavirus DNA
- see ARUP consult[5]
Management
- decrease immunosuppression if BK virus-associated nephropathy
- most antiviral agents, including acyclovir & ganciclovir are ineffective
- cidofovir, fluoroquinolones, leflunomide seem to have some activity against BK virus
Comparative biology
- BK virus causes tumors in hamsters
More general terms
References
- ↑ Greenfield's Neuropathology, 5th ed., 1992 p. 367
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1066-67
- ↑ 3.0 3.1 FDA Medwatch http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm171828.htm
- ↑ Mylonakis E et al BK virus in solid organ transplant recipients: an emerging syndrome. Transplantation. 2001 Nov 27;72(10):1587-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11726814
- ↑ 5.0 5.1 ARUP Consult: BK Virus The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/bk-virus
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 16,17,18. American College of Physicians, Philadelphia 2012,2015,2018.
- ↑ Barraclough KA, Isbel NM, Staatz CE, Johnson DW. BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression. J Transplant. 2011;2011:750836 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21766009