FK506-binding protein 1B (12.6 kD FK506-binding protein, immunophilin FKBP12.6, FKBP1B)
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Function
- negative regulator of ryanodine receptor Ca2+ release
- interacts directly with RYR2
- may contribute to the immunosuppressive & toxic effects of FK506 & rapamycin
- rotamases accelerate the folding of proteins
- catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
- inhibited by both FK506 & rapamycin
- component of AKAP6/FKBP1B/PKA catalytic/PP1/PP2A/PRKAR2A/RYR2 complex
Structure
Compartment
Alternative splicing
named isoforms=2
Expression
- detected in heart muscle (at protein level)
- isoform 1 & isoform 2 are ubiquitous with highest levels in brain & thymus
Comparative biology
- overexpression of FKBP1b in hippocampus of rats reverses age- associateed memory impairment & neuronal Ca+2 dysregulation[1]
More general terms
References
- ↑ 1.0 1.1 UniProt http://www.uniprot.org/uniprot/P68106.html
- ↑ Gant JC, Blalock EM, Chen KC et al FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats. J Neurosci. 2017 Dec 18, 2234-17 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29255009 <Internet> http://www.jneurosci.org/content/early/2017/12/18/JNEUROSCI.2234-17.2017