restenosis
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Introduction
The recurrence of a stenosis in a coronary artery.
Management
- NOT prevented by homocysteine-lowering* therapy of vitamin B6, vitamin B12 & folate #
- drug-eluting stent superior to vascular brachytherapy[2]
* average serum homocysteine lowered from 12 to 9 umol/L
# see trans-sulfuration pathway
Comparative biology
- oral dichloroacetate reduces neointimal proliferation following balloon injury in arteries of several mammals, including human arteries placed into mice[3]
More general terms
References
- ↑ Lange H, Suryapranata H, De Luca G, Borner C, Dille J, Kallmayer K, Pasalary MN, Scherer E, Dambrink JH. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med. 2004 Jun 24;350(26):2673-81. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15215483
- ↑ 2.0 2.1 Stone GW et al, TAXUS V ISR Investigators Paclitaxel-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents. The TAXUS V ISR randomized trial. JAMA 2006; 295:1253 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16531618
Holmes DR Jr et al, SISR Investigators Sirolimus-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents. The SISR randomized trial. JAMA 2006; 295:1264 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16531619
Mukherjee D and Moliiterno DJ Brachytherapy for in-stent restenosis: A distant second choice to drug-eluting stent placement. JAMA 2006; 295:1307 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16531620 - ↑ 3.0 3.1 Deuse T et al. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature 2014 May 29; 509:641 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24747400 <Internet> http://www.nature.com/nature/journal/v509/n7502/full/nature13232.html