homocysteine in serum/plasma

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Indications

  • no role for routine measurement[2]

Reference interval

Clinical significance

Increased homocysteine levels are a risk factor* for:

* risk appears to increase at levels of > 8 umol/L modest risk factor[6]

# Risk increased 4-fold for homocysteine levels > 18 umol/L[2]

% 2-fold risk of dementia for homocysteine levels of 14 umol/L

$ NO benefit of lowering serum homocysteine in secondary stroke prevention[7]

Toxicity:

Determinants of homocysteine levels include:

Increases

Methods

Assays for homocysteine:

Specimen

More general terms

More specific terms

Additional terms

Component of

References

  1. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993
  2. Jump up to: 2.0 2.1 2.2 2.3 Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
  3. Carmel R, Ann Rev Med 51:357, 2000
  4. Jump up to: 4.0 4.1 Journal Watch 22(7):56-57, 2002 Seshadri S et al, N Engl J Med 346:476, 2002
  5. Jump up to: 5.0 5.1 Journal Watch 22(12):92, 2002 Ridker PM et al, Circulation 105:1776, 2002
  6. Jump up to: 6.0 6.1 Journal Watch 22(24):181, 2002 Homocysteine Studies Collaboration, JAMA 288:2015, 2002 Kirk M et al, JAMA 288:2023, 2002 Wilson PWF, JAMA 288:2042, 2002
  7. Jump up to: 7.0 7.1 Journal Watch 24(5):8, 2004 Toole JF et al, JAMA 291:565, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14762035
  8. Panel of 6 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030133.jsp
  9. Panel of 16 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030268.jsp
  10. Homocysteine, Total Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0099869.jsp