homocysteine in serum/plasma

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Indications

  • no role for routine measurement[2]

Reference interval

Clinical significance

Increased homocysteine levels are a risk factor* for:

* risk appears to increase at levels of > 8 umol/L modest risk factor[6]

# Risk increased 4-fold for homocysteine levels > 18 umol/L[2]

% 2-fold risk of dementia for homocysteine levels of 14 umol/L

$ NO benefit of lowering serum homocysteine in secondary stroke prevention[7]

Toxicity:

Determinants of homocysteine levels include:

Increases

Methods

Assays for homocysteine:

Specimen

More general terms

More specific terms

Additional terms

Component of

References

  1. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993
  2. 2.0 2.1 2.2 2.3 Medical Knowledge Self Assessment Program (MKSAP) 11, 17. American College of Physicians, Philadelphia 1998, 2015
  3. Carmel R, Ann Rev Med 51:357, 2000
  4. 4.0 4.1 Journal Watch 22(7):56-57, 2002 Seshadri S et al, N Engl J Med 346:476, 2002
  5. 5.0 5.1 Journal Watch 22(12):92, 2002 Ridker PM et al, Circulation 105:1776, 2002
  6. 6.0 6.1 Journal Watch 22(24):181, 2002 Homocysteine Studies Collaboration, JAMA 288:2015, 2002 Kirk M et al, JAMA 288:2023, 2002 Wilson PWF, JAMA 288:2042, 2002
  7. 7.0 7.1 Journal Watch 24(5):8, 2004 Toole JF et al, JAMA 291:565, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14762035
  8. Panel of 6 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030133.jsp
  9. Panel of 16 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030268.jsp
  10. Homocysteine, Total Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0099869.jsp