FK506-binding protein 2 (13 kD FK506-binding protein, FKBP2)

Function

• associates with ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum
• may play a physiological role in excitation-contraction coupling in cardiac muscle
• there are four molecules of FKBP12.6 per heart muscle RYR
• PPIases accelerate the folding of proteins
• catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides inhibited by both FK506 & rapamycin

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the FKBP-type PPIase family, FKBP1 subfamily
• contains 1 PPIase FKBP-type domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

• ubiquitous for both isoform
• highest levels in brain & thymus

Pathology

• may contribute to the immunosuppressive & toxic effects of FK506 & rapamycin.

More general terms

• FK506 binding protein (FKBP)

Database

• UniProt: http://www.uniprot.org/uniprot/P26885.html
• OMIM: https://mirror.omim.org/entry/186946