protein (total) in serum
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Reference interval
- Male & Female: 6.3 - 8.3 g/dL
- serum albumin: 3.5-5.1 g/dL
- serum globulin: 2.5-3.5 g/dL
Principle
Clinical significance
Serum proteins function to transport drugs & metabolites, & they maintain the plasma osmotic pressure. The majority of serum proteins are synthesized in the liver with the exception of gamma globulins. One of the most important serum proteins produced in the liver is albumin. The total serum protein can be used for evaluation of the nutritional status.
Increases
- causes of high total serum protein include
- dehydration
- Waldenstrom's macroglobulinemia
- multiple myeloma
- hypergammaglobulinemia
- granulomatous disease
- some tropical diseases.
- total protein is occasionally increased in
- connective tissue diseases
- lupus erythematosus
- other instances of chronic infection or inflammation
- pharmaceutical agents:
- in vivo effects
- chemical interferences
- bromsulphalein (BSP) dye, bilirubin, dextran, phenazopyridine
Decreases
- causes of low total serum protein include
- pregnancy
- excessive intravenous fluid administration
- cirrhosis or other liver diseases,
- chronic alcoholism
- heart failure
- nephrotic syndrome
- glomerulonephritis
- neoplasia
- protein losing enteropathies
- malabsorption
- severe malnutrition
- pharmaceutical agents:
- chemical interferences
Specimen
Interferences
More general terms
More specific terms
Additional terms
Component of
- chemistry 14 panel (comprehensive metabolic panel, CMP, chem 12, SMA12, SMA20)
- protein/creatinine in serum/plasma
- calcium/protein in serum/plasma
- alpha-2-macroglobulin/total protein in serum
- beta-2 globulin/total protein in serum
- beta-1 globulin/total protein in serum
- alpha-2 globulin/protein.total in serum/plasma
- alpha-1 globulin/protein.total in serum/plasma
- parathyroid panel
- liver (function) tests (LFT, liver panel, hepatic function panel)
- enteral/parenteral nutrition management panel
- bone/joint panel
- albumin/protein total in serum
References
- ↑ Kodak Ektachem 700 Analyzer Operator's Manual, Kodak Clinical Products, Rochester, New York.
- ↑ Kodak Ektachem Slide Package Inserts, Kodak Clinical Products Rochester, New York.
- ↑ Kodak Ektachem Training Manual, Kodak Clinical Products, Rochester, New York.
- ↑ Young, D. S., Pestaner, L. C., Gibberman, V: Effects of drugs on clinical chemistry tests. Clinical Chemistry (Special Issue) 21, April 1975.
- ↑ Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 11.
- ↑ Protein, Total, Serum or Plasma Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0020029.jsp
- ↑ Panel of 15 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0020408.jsp
- ↑ Panel of 7 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0020416.jsp
- ↑ Panel of 10 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050615.jsp
- ↑ Panel of 6 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050640.jsp
- ↑ Panel of 17 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0051223.jsp
- ↑ Panel of 16 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0051225.jsp
- ↑ Panel of 7 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0000000.jsp
- ↑ Panel of 10 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0000000.jsp