granulomatous disease
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Etiology
- Diseases associated with the formation of granulomas:
- sarcoidosis
- tuberculosis: granulomas may have a central area of necrosis (caseous necrosis) rare in other granulomatous diseases
- fungal infections
- brucellosis
- tularemia
- syphilis
- leprosy
- Hodgkin's disease
- drug reactions
- vasculitis
- cat scratch disease
- berylliosis
- lymphogranuloma inguinale
Pathology
- granulomas contain macrophages that possess CYP27B1, the 25-hydroxyvitamin D-1 alpha hydroxylase that forms calcitriol from calcifediol, resulting in hypercalcemia
More general terms
More specific terms
- berylliosis
- botryomycosis
- bronchocentric granulomatosis
- brucellosis
- cerebral granulomatous angiitis
- chronic granulomatous disease
- donovanosis (granuloma inguinale, granuloma venereum)
- granulomatosis with polyangiitis; Wegener's granulomatosis
- Langerhans cell histiocytosis (LCH); histiocytosis X
- leprosy (Hansen's disease)
- lymphogranuloma venereum (inguinale); Favre-Durand-Nicholas disease; tropical bubo
- malakoplakia
- midline granuloma (facial granuloma)
- mycosis; fungal infection
- rhinosporidiosis
- sarcoidosis
- syphilis
- tuberculosis
Additional terms
References
- ↑ Internal Medicine, J Stein (ed), Little, Brown & Co, Boston, 1983, pg 1091
- ↑ Cotran et al Robbins Pathologic Basis of Disease, 5th ed. W.B. Saunders Co, Philadelphia, PA 1994 pg 82
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
- ↑ Sharma OP. Hypercalcemia in granulomatous disorders: a clinical review. Curr Opin Pulm Med. 2000 Sep;6(5):442-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10958237