phenazopyridine (Pyridium, Azo-Standard, Uristat, Prodium)

Introduction

Tradename: Pyridium.

Indications

• symptomatic relief of dysuria*
  • pain, burning, urinary urgency & urinary frequency arising from irritation of the lower urinary tract
  • caused by urinary tract infection
  • following urological procedures

* does NOT provide antimicrobial coverage

Dosage

• 100-200 mg PO TID after meals for 2 days
• do NOT use chronically
• adequate hydration is needed

Tabs: 100 & 200 mg.

Adverse effects

• not common (1-10%)
  • headache, dizziness, epigastric cramps
• uncommon (< 1%)
  • vertigo, skin pigmentation, rash, methemoglobinemia, hemolytic anemia, hepatitis, acute renal failure
• other
  • anaphylactoid-like reactions
  • will turn urine orange
  • will stain clothes & contact lenses

Mechanism of action

• azo dye that exerts a topical analgesic effect on the urinary mucosal tract

More general terms

• pyridine
• analgesic (antalgic)

Component of

• phenazopyridine/sulfamethoxazole/trimethoprim
• oxytetracycline/phenazopyridine
• butabarbital/hyoscyamine/phenazopyridine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4756
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8691
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=657215