eukaryotic translation initiation factor 4E (eIF4E, mRNA cap-binding protein)

Function

• binds to 5'cap in mRNA
• phosphorylation appears to essential for activity
• overexpression of eIF-4E results in cell transformation

Structure

• multi-subunit complex, the composition of which varies with external & internal environmental conditions
• composed of at least eIF4A, eIF4E & eIF4G

More general terms

• initiation factor
• RNA-binding protein
• phosphoprotein

Additional terms

• eukaryotic translation initiation factor 4E type 1B (EIF4E1B)
• eIF4E type 3
• eukaryotic translation initiation factor 4E type 3; eIF-4E type 3; eIF-4E3; eIF4E type 3; eIF4E-3 (EIF4E3)
• nuclear mRNA cap-binding protein
• protein synthesis

Database

• UniProt: http://www.uniprot.org/uniprot/P06730.html
• OMIM: https://mirror.omim.org/entry/133440
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1977