eukaryotic translation initiation factor 4E type 3; eIF-4E type 3; eIF-4E3; eIF4E type 3; eIF4E-3 (EIF4E3)

Function

• recognizes & binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis
• may act as an inhibitor of EIF4E1 activity
• component of eIF4F
• EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 EIF4EBP3 (putative)

Structure

belongs to the eukaryotic initiation factor 4E family

Alternative splicing

named isoforms=2

More general terms

• initiation factor
• human longevity protein

Additional terms

• eukaryotic translation initiation factor 4E (eIF4E, mRNA cap-binding protein)

Component of

• eukaryotic translation initiation factor 4F (eIF4F)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=317649
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:317649
• OMIM: https://mirror.omim.org/entry/609896
• UniProt: http://www.uniprot.org/uniprot/Q8N5X7.html