Rapamycin-insensitive companion of mTOR (RICTOR, KIAA1999)

Function

• role in embryonic growth & development (putative)
• part of the TORC2 complex which plays a role in AKT1 Ser-473 phosphorylation, & may modulate phosphorylation of PKCA & regulate actin cytoskeleton organization
• forms part of the mammalian target of rapamycin 2 complex (TORC2 complex)
• binds directly to FRAP1 & PRR5 within the TORC2 complex

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein

Component of

• target of rapamycin 2 complex (TORC2 complex)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6R327.html