protein kinase C-alpha (PKC-III, PRKCA, PKCA PRKACA)
Jump to navigation
Jump to search
Function
- Ca+2-activated, phospholipid-dependent serine/threonine kinase
- may play a role in cell motility by phosphorylating CSPG4
- activated by diacylglycerol
- phosphorylates a range of cellular proteins
- interacts with CENTA1, CSPG4 & PRKCABP
- binds to SDPR in the presence of phosphatidylserine
Structure
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 1 C2 domain
- contains 2 phorbol-ester/DAG-type Zn+2 fingers
- contains 1 protein kinase domain
More general terms
References
- ↑ Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2238044
- ↑ UniProt http://www.uniprot.org/uniprot/P17252.html