centaurin-alpha-1; MAPK-activating protein PM25 (CENTA1, ADAP1)

Function

• GTPase-activating protein for the ADP ribosylation factor family
• binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) & inositol 1,3,4,5-tetrakisphosphate (InsP4)
• interacts with PRKCA, PRKCI, PRKCZ
• interacts with N-terminal region of PRKD1
• phosphorylated by PRKCA, PRKCI, PRKCZ, PRKD1 in vitro

Compartment

• nucleus, cytoplasm
• recruited to the plasma membrane upon epidermal growth factor-dependent activation of PI-4,5-diphosphate 3-kinase

Expression

• expressed in brain > peripheral blood leukocytes

More general terms

• centaurin
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608114
• UniProt: http://www.uniprot.org/uniprot/O75689.html