target of rapamycin complex subunit LST8; TORC subunit LST8; G protein beta subunit-like; Gable; protein GbetaL; mammalian lethal with SEC13 protein 8; mLST8 (MLST8, GBL, LST8)

Function

• subunit of both mTORC1 & mTORC2, which regulate cell growth & survival in response to nutrient & hormonal signals
• within mTORC1, LST8 interacts directly with MTOR & enhances its kinase activity
• in nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction & favors RPTOR-mediated inhibition of MTOR activity
• interacts directly with MTOR & RPTOR
• interacts with RHEB
• phosphorylated on Ser-7

Structure

• belongs to the WD repeat LST8 family
• contains 7 WD repeats

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

Expression

• broadly expressed
• highest levels in skeletal muscle, heart & kidney

More general terms

• phosphoprotein
• WD repeat protein family

Component of

• target of rapamycin 1 complex (TORC1 complex)
• target of rapamycin 2 complex (TORC2 complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64223
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64223
• OMIM: https://mirror.omim.org/entry/612190
• UniProt: http://www.uniprot.org/uniprot/Q9BVC4.html