target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1; mitogen-activated protein kinase 2-associated protein 1; stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1 (MAPKAP1, MIP1, SIN1)

Function

• subunit of mTORC2
• within mTORC2, MAPKAP1 is required for complex formation & mTORC2 kinase activity
• MAPKAP1 inhibits MAP3K2 by preventing its dimerization & autophosphorylation
• inhibits HRAS & KRAS signaling
• enhances osmotic stress-induced phosphorylation of ATF2 & ATF2-mediated transcription
• interacts with IFNAR2 (putative)
• all isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2)
• interacts with ATF2, MAP3K2 & MAPK8
• interacts with GTP-bound HRAS & KRAS

Structure

belongs to the SIN1 family

Compartment

• cell membrane; peripheral membrane protein
• cytoplasmic vesicle
• nucleus

Alternative splicing

• named isoforms=6
• apparently, not all isoforms involved in a TORC2 complex

Expression

• ubiquitously expressed
• highest levels of expression in heart & skeletal muscle

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79109
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79109
• OMIM: https://mirror.omim.org/entry/610558
• UniProt: http://www.uniprot.org/uniprot/Q9BPZ7.html