mitogen-activated protein kinase kinase kinase 2 (MAP3K2, MAPK/ERK kinase kinase 2, MEKK2, MAPKKK2)

Function

• component of a protein kinase signal transduction cascade
• regulates the JNK & ERK5 pathways by phosphorylating & activating MAP2K5 & MAP2K7 (putative)
• plays a role in caveolae kiss-&-run dynamics
• binds both upstream activators & downstream substrates in multimolecular complexes
• activated by phosphorylation on Thr-524
• autophosphorylated (putative)

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily contains 1 OPR domain
• contains 1 protein kinase domain

Compartment

• cytoplasm
• upon EGF stimulation, translocates into the nucleus

More general terms

• MAP3K/MEKK

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y2U5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10746