serine/threonine protein kinase Kist; kinase interacting with stathmin; U2AF homology motif kinase 1 (UHMK1, KIS, KIST)

Function

• upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location & cell cycle progression in G1 phase
• may be involved in trafficking &/or processing of RNA (putative)
• interacts with stathmin & CDKN1B/p27Kip1

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain
• contains 1 RRM domain (RNA recognition motif)

Compartment

• nucleus
• mostly nuclear

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest levels in skeletal muscle, kidney, placenta & peripheral blood leukocytes
• induced by serum growth factors (putative)

More general terms

• serine/threonine kinase
• nuclear protein
• RNA-binding protein

Additional terms

• atathmin; phosphoprotein p19; pp19; leukemia-associated phosphoprotein p18; oncoprotein 18; Op18; pp17; prosolin; metablastin; protein Pr22 (STMN1, LAP18, OP18)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=127933
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:127933
• OMIM: https://mirror.omim.org/entry/608849
• UniProt: http://www.uniprot.org/uniprot/Q8TAS1.html