mitogen activated protein kinase kinase 7 (dual specificity mitogen-activated protein kinase kinase 7, JNK-activating kinase 2, c-jun N-terminal kinase kinase-2, JNKK2, MAPK/ERK kinase 7, MAP2K7, MEK7, MKK7, PRKMK7)

Function

• stress activated, dual specificity kinase
• activates JUN kinases MAPK8/JNK1, MAPK9/JNK2 & MAPK10/JNK3
• activated by phosphorylation by specific MEK kinases such a MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 & MAP3K12/DLK
• activated by phosphorylation on Ser/Thr

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family. MAP kinase kinase subfamily
• contains 1 protein kinase domain

Compartment

nucleus. cytoplasm (putative)

Alternative splicing

named isoforms=4

Expression

• ubiquitous
• highest level of expression in skeletal muscle
• isoform 3 is found at low levels in placenta, fetal liver, & skeletal muscle

More general terms

• MAP2K/MEK

Database

• UniProt: http://www.uniprot.org/uniprot/O14733.html
• OMIM: https://mirror.omim.org/entry/603014
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5609