protein phosphatase Slingshot homolog 1; SSH-1L; hSSH-1L (SSH1, SSH1L)

Function

• regulates actin filament dynamics
• dephosphorylates & activates cofilin (disassembles actin)
• LIMK1 phosphorylates & deactivates cofilin
• interacts with 14-3-3 proteins YWHAB, YWHAG, YWHAQ, & YWHAZ
• inhibits phosphatase activity
• inhibitory phosphorylation by PAK4 promotes binding to YWHAZ
• dephosphorylated & activated by calcineurin A

Structure

• belongs to the protein-tyrosine phosphatase family
• contains 1 tyrosine-protein phosphatase domain

Compartment

• cytoplasm
• also recruited to actin rich-membrane protrusions, lamellipodia for cell locomotion
• also localized to the cleavage furrow & the midbody during cytokinesis

Alternative splicing

• named isoforms=5
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• protein phosphatase Slingshot homolog (ssH)

Database

• OMIM: https://mirror.omim.org/entry/606778
• UniProt: http://www.uniprot.org/uniprot/Q8WYL5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54434
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54434