14-3-3 protein gamma; protein kinase C inhibitor protein 1; KCIP-1 (YWHAG)

Function

• adapter protein implicated in regulation of both general & specialized signaling pathways.
• binds to many protein, usually by recognition of a phospho-Ser or phospho-Thr motif
• binding generally results in modulation of the activity of the binding partner
• phosphorylated by various PKC isozymes
• interacts with RAF1, SSH1 & CRTC2/TORC2

Structure

• homodimer
• belongs to the 14-3-3 family

Compartment

cytoplasm (putative)

Expression

• highly expressed in brain, skeletal muscle, & heart

More general terms

• 14-3-3 protein (KCIP-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7532
• OMIM: https://mirror.omim.org/entry/605356
• UniProt: http://www.uniprot.org/uniprot/P61981.html