cofilin
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Function
- cofilin has weak F-actin severing activity
- binds to actin monomers.
- appears to 'nibble' monomer from F-actin leaving free barbed end
- action similar to destrin
- phospholipid binding may reduce affinity for G-actin[1]
- phosphorylation deactivates cofilin; dephosphorylation activates
- phosphorylated by LIMK1
- dephosphorylated by SSH2, SSH3
More general terms
More specific terms
- cofilin-1; cofilin, non-muscle isoform; 18 kD phosphoprotein; p18 (CFL1 CFL)
- cofilin-2; cofilin, muscle isoform (CFL2)
Additional terms
References
- ↑ Jump up to: 1.0 1.1 Stossel TP. On the crawling of animal cells. Science. 1993 May 21;260(5111):1086-94. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8493552
- ↑ UniProt http://www.uniprot.org/uniprot/Q76I76.html