destrin; actin-depolymerizing factor; ADF (DSTN ACTDP DSN)

Function

• destrin has weak F-actin severing activity
• binds to actin monomers
• appears to 'nibble' monomer from F-actin leaving free barbed end.
• action similar to cofilin
• phospholipid binding may reduce affinity for G-actin
• pH-independent action

Structure

• belongs to the actin-binding proteins ADF family
• contains 1 ADF-H domain

Expression

widely distributed in various tissues

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P60981.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11034
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11034
• OMIM: https://mirror.omim.org/entry/609114