protein phosphatase Slingshot homolog 3; SSH-like protein 3; SSH-3L; hSSH-3L (SSH3, SSH3L)

Function

• regulates actin filament dynamics
• dephosphorylates & activates cofilin (disassembles actin); (LIMK1 phosphorylates & deactivates cofilin)
• phosphorylated upon DNA damage, probably by ATM or ATR
• does not bind to, or colocalize with, filamentous actin

Structure

• belongs to the protein-tyrosine phosphatase family
• contains 1 tyrosine-protein phosphatase domain

Compartment

• cytoplasm, cytoskeleton (putative)
• nucleus (putative)

Alternative splicing

named isoforms=5

More general terms

• protein phosphatase Slingshot homolog (ssH)

Database

• OMIM: https://mirror.omim.org/entry/606780
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54961
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54961
• UniProt: http://www.uniprot.org/uniprot/Q8TE77.html