son of sevenless homolog protein 1 (Sos1)
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Function
- promotes the exchange of Ras-bound GDP by GTP
- interacts with GRB2
- interacts with phosphorylated LAT2
Structure
- contains 1 DH (DBL-homology) domain contains 1 N-terminal Ras-GEF domain contains 1 PH domain contains 1 Ras-GEF domain
Expression
expressed in gingival tissues
Pathology
- defects in SOS1 are the cause of gingival fibromatosis 1
- defects in SOS1 are the cause of Noonan syndrome type 4
More general terms
Additional terms
Component of
References
- ↑ Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature. 1993 May 6;363(6424):45-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8479536
- ↑ Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993 May 28;260(5112):1338-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8493579
- ↑ Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature. 1993 Dec 16;366(6456):643-54. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SOS1
- ↑ Wikipedia; Note=Son of sevenless entry http://en.wikipedia.org/wiki/Son_of_Sevenless
- ↑ UniProt http://www.uniprot.org/uniprot/Q07889.html