Rap guanine nucleotide exchange factor 2 (PDZ domain-containing guanine nucleotide exchange factor 1, neural RAP guanine nucleotide exchange protein, nRap GEP, PDZ-GEF1, RA-GEF, RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1)

Function

• guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B, Rap2B GTPases
• does NOT interact with cAMP or cGMP
• interacts with MAGI2

Compartment

• cell membrane
• associated with synaptic plasma membrane (putative)

Expression

expressed in brain > heart, kidney, lung, placenta

More general terms

• guanine nucleotide exchange factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y4G8.html