ALS2 C-terminal-like protein (ALS2CL)

Function

• acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase
• regulates the ALS2-mediated endosome dynamics
• forms a heteromeric complex with ALS2
• interacts with ALS2 & RAB5A

Structure

• homodimer
• contains 8 MORN repeats
• contains 1 VPS9 domain

Compartment

• cytoplasm
• distributed onto vesicular compartments in the cytoplasm with strong punctated staining
• colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of cells

Alternative splicing

named isoforms=5

Expression

expressed in heart & kidney

More general terms

• guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q60I27.html