protein SOLO (SOLO, ARHGEF40)

Function

• may act as a guanine nucleotide exchange factor (GEF)

Structure

• contains 1 DH (DBL-homology) domain
• contains 1 PH domain

Compartment

• cytoplasm
• concentrated in the perinuclear region

Alternative splicing

named isoforms=4

Expression

• expressed at high level in the central nervous system & skeletal muscle
• greater abundance in fetal than adult brain (at protein level)

More general terms

• guanine nucleotide exchange factor

Additional terms

• SEC14 domain & spectrin repeat-containing protein 1 (huntingtin-interacting protein-like protein, protein solo, SESTD1, SOLO)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5570
• UniProt: http://www.uniprot.org/uniprot/Q8TER5.html