FYVE, RhoGEF & PH domain-containing protein 4 (actin filament-binding protein frabin, FGD1-related F-actin-binding protein, zinc finger FYVE domain-containing protein 6, FGD4, FRABP, ZFYVE6)

Function

• activates CDC42 by exchanging bound GDP for free GTP
• role in regulating actin cytoskeleton & cell shape, microspike formation
• activates MAPK8

Structure

• homooligomer
• contains 1 DH domain (DBL-homology domain)
• contains 1 FYVE-type zinc finger
• contains 2 PH domains
• part of protein spanning actin filament-binding domain together with DH domain & 1st PH domain necessary & sufficient for microspike formation
• activation of MAPK8 requires the presence of all domains with the exception of the actin filament-binding domain

Compartment

• cytoplasm, cytoskeleton, cell projection, filopodium
• concentrated in filopodia & poorly detected at lamellipodia
• binds along thesides of actin fibers

Alternative splicing

named isoforms=3

More general terms

• guanine nucleotide exchange factor
• zinc finger FYVE domain-containing protein (ZFYVE)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96M96.html