rap1 GTPase-GDP dissociation stimulator 1; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein; exchange factor smgGDS (RAP1GDS1)

Function

• guanine nucleotide exchange factor
• stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including rap1a/rap1b, RhoA, RhoB & KRas, by stimulating dissociation of GDP from & the subsequent binding of GTP to each small G protein

Structure

contains 5 ARM repeats

Alternative splicing

named isoforms=2

More general terms

• guanine nucleotide exchange factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5910
• OMIM: https://mirror.omim.org/entry/179502
• UniProt: http://www.uniprot.org/uniprot/P52306.html