Ras-GEF domain-containing family member 1A (RASGEF1A)

Function

• guanine nucleotide exchange factor (GEF) for KRAS, HRAS, & NRAS (in vitro)
• role in cell migration

Structure

• contains 1 N-terminal Ras-GEF domain
• contains 1 Ras-GEF domain

Alternative splicing

named isoforms=2

Expression

• detected in brain & spinal cord

Pathology

• highly expressed in a number of intrahepatic cholangiocarcinoma tissue biopsies

More general terms

• guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N9B8.html