prolactin regulatory element-binding protein; mammalian guanine nucleotide exchange factor msec12 (PREB, SEC12)

Function

• first identified based on its probable role in the regulation of pituitary gene transcription
• binds to the prolactin gene promoter & seems to activate transcription
• guanine nucleotide exchange factor that activates SARA2
• required for the formation of COP2 transport vesicles from the ER
• binds SARA2

Structure

contains 3 WD repeats

Compartment

• nucleus (putative)
• endoplasmic reticulum membrane
• single-pass membrane protein (putative)

Expression

ubiquitous

More general terms

• guanine nucleotide exchange factor
• transcription factor (TF)
• WD repeat protein family
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10113
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10113
• OMIM: https://mirror.omim.org/entry/606395
• UniProt: http://www.uniprot.org/uniprot/Q9HCU5.html