phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; P-Rex1; Ptdins(3,4,5)-dependent Rac exchanger 1 (PREX1, KIAA1415)

Function

• RAC guanine nucleotide exchange factor (GEF), which activates Rac proteins by exchanging bound GDP for free GTP
• synergistically activated by PI-3,4,5-triphosphate & G-beta-gamma
• may function downstream of heterotrimeric G proteins in neutrophils
• interacts preferentially with RAC2 (putative)
• interacts with RAC1

Structure

• contains 1 DEP domain
• contains 1 DH (DBL-homology) domain
• contains 1 PDZ domain (DHR domain)
• contains 2 PH domains

Compartment

• cytoplasm, cell membrane
• mainly cytosolic
• some amount is associated with the plasma membrane

Alternative splicing

named isoforms=3

Expression

• mainly expressed in peripheral blood leukocytes & brain
• expressed at intermediate level in spleen & lymph nodes
• weakly expressed in other tissues

More general terms

• guanine nucleotide exchange factor
• phosphoprotein
• human longevity protein

Additional terms

• rac proto-oncogene protein (p21rac)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57580
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57580
• OMIM: https://mirror.omim.org/entry/606905
• UniProt: http://www.uniprot.org/uniprot/Q8TCU6.html