brefeldin A-inhibited guanine nucleotide-exchange protein 1; brefeldin A-inhibited GEP 1; p200 ARF-GEP1; p200 ARF guanine nucleotide exchange factor (ARFGEF1, ARFGEP1, BIG1)

Function

• promotes guanine-nucleotide exchange on ARF1 & ARF3
• promotes activation of ARF1/ARF3 through replacement of GDP with GTP
• inhibited by brefeldin A
• interacts with FKBP2
• interacts with DPY30

Structure

contains 1 SEC7 domain

Expression

• expressed in placenta, lung, heart, brain, kidney & pancreas

More general terms

• guanine nucleotide exchange factor

Additional terms

• brefeldin A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10565
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10565
• OMIM: https://mirror.omim.org/entry/604141
• UniProt: http://www.uniprot.org/uniprot/Q9Y6D6.html