guanine nucleotide exchange factor DBS; DBL's big sister; MCF2-transforming sequence-like protein (MCF2L, KIAA0362)

Function

• guanine nucleotide exchange factor
• potentially links pathways that signal through RAC1, RHOA & CDC42
• catalyzes guanine nucleotide exchange on RHOA & CDC42 & interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1 may also participate in axonal transport in the brain
• becomes activated & highly tumorigenic by truncation of the N-terminus (putative)
• isoform 5 activates CDC42
• interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA (putative)
• interacts with an array of inositol phospholipids such as
  • phosphatidylinositol 3-phosphate (PI3P)
  • phosphatidylinositol 4-phosphate (PI4P)
  • phosphatidylinositol 5-phosphate (PI5P)

Structure

• the CRAL-TRIO domain is involved in interaction with inositol phospholipids
• the DH domain is involved in interaction with CCPG1
• belongs to the MCF2 family
• contains 1 CRAL-TRIO domain
• contains 1 DH (DBL-homology) domain
• contains 1 PH domain
• contains 1 SH3 domain
• contains 1 spectrin repeat

Compartment

• cytoplasm (putative)
• plasma membrane, cytoplasmic side (putative)

Alternative splicing

named isoforms=8

More general terms

• guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23263
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23263
• OMIM: https://mirror.omim.org/entry/609499
• UniProt: http://www.uniprot.org/uniprot/O15068.html