cell cycle progression protein 1 (cell cycle progression restoration protein 8, CCPG1, CCP8, CPR8, KIAA1254)

Function

• acts as an assembly platform for Rho protein signaling complexes
• limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability & its transforming activity
• does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (putative)
• may be involved in cell cycle regulation
• interacts with MCF2L
• may interact with MCF2, ARHGEF1, BCR, VAV1 & FGD1, but not with TIAM1
• interacts with GTP-bound CDC42 & SRC (putative)

Structure

belongs to the CCPG1 family

Compartment

• cytoplasmic granule membrane

Alternative splicing

named isoforms=4

More general terms

• phosphoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9ULG6.html