Rho guanine nucleotide exchange factor 1; 115 kD guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; sub1.5 (ARHGEF1)
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Function
- seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) & guanine nucleotide-binding alpha-13 (GNA13) subunits
- acts as GTPase-activating protein (GAP) for GNA12 & GNA13, & as guanine nucleotide exchange factor (GEF) for RhoA GTPase
- activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain
- RhoGEF activity is inhibited by binding to activated GNA12
- mediates angiotensin-2-induced RhoA activation
- phosphorylated by PKCA
- angiotensin-2 induced Tyr-738
- phosphorylation is mediated by JAK2
- interacts with RHOA, GNA12 & GNA13
- homooligomerizes through the coiled coil region
- may interact with CCPG1
- interacts with CTNNAL1
Structure
- the RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity
- the DH domain is involved in interaction with CCPG1
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 RGSL (RGS-like) domain
Compartment
Alternative splicing
named isoforms=3
Expression
ubiquitously expressed