cytohesin ADP Ribosylation Factor (ARF) nucleotide binding site opener (ARNO)

Introduction

A family of proteins that share function & structure.

Function

• guanine-nucleotide exchange factors (GEFs) for ARFs

Structure

• C-terminal pleckstrin homology domain (PH domain)
• central 200-amino acid region similar to a domain within the yeast Sec7 protein, which is required for vesicular traffic of polypeptides through the Golgi

Notes

• ARNO may be cytohesin-2

More general terms

• guanine nucleotide exchange factor

More specific terms

• cytohesin-1; PH, SEC7 & coiled-coil domain-containing protein 1; SEC7 homolog B2-1; ARF nucleotide binding site opener-1; ARNO-1 (CYTH1, D17S811E, PSCD1)
• cytohesin-2; PH, SEC7 & coiled-coil domain-containing protein 2; ARF nucleotide-binding site opener; protein ARNO; ARF exchange factor (CYTH2 ARNO PSCD2 PSCD2L)
• cytohesin-3; PH, SEC7 & coiled-coil domain-containing protein 3; ARF nucleotide-binding site opener 3; protein ARNO3; general receptor of phosphoinositides 1; Grp1 (CYTH3, ARNO3, GRP1, PSCD3)
• cytohesin-4; PH, SEC7 & coiled-coil domain-containing protein 4; ARF nucleotide binding site opener-4; ARNO-4 (CYTH4 CYT4 PSCD4)

Database

• OMIM: https://mirror.omim.org/entry/605081