cytohesin-1; PH, SEC7 & coiled-coil domain-containing protein 1; SEC7 homolog B2-1; ARF nucleotide binding site opener-1; ARNO-1 (CYTH1, D17S811E, PSCD1)

Function

• promotes guanine-nucleotide exchange on ARF1 & ARF5
• promotes the activation of ARF through replacement of GDP with GTP
• interacts with TRIM23 & CYTIP

Structure

• contains 1 PH domain
• contains 1 SEC7 domain

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• cytohesin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9267
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9267
• OMIM: https://mirror.omim.org/entry/182115
• UniProt: http://www.uniprot.org/uniprot/Q15438.html