GTP-binding protein ARD1; ADP-ribosylation factor domain-containing protein 1; tripartite motif-containing protein 23; RING finger protein 46 (TRIM23, ARD1, ARFD1, RNF46)

Function

• not known
• the C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit
• interacts with PSCD1

Structure

• in the C-terminal section; belongs to the small GTPase superfamily, Arf family
• contains 1 B box-type Zn+2 finger
• contains 1 RING-type Zn+2 finger

Compartment

• endomembrane system, Golgi membrane, lysosome membrane
• membrane-associated with the Golgi complex & lysosomal structures

Alternative splicing

named isoforms=3; alpha, beta, gamma

More general terms

• guanine nucleotide regulatory protein (GNRP)
• tripartite motif-containing protein (trim protein)

Additional terms

• N-terminal acetyltransferase complex ARD1 subunit homolog A (ARD1A, ARD1, TE2, NAA10)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=373
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:373
• OMIM: https://mirror.omim.org/entry/601747
• UniProt: http://www.uniprot.org/uniprot/P36406.html