N-terminal acetyltransferase complex ARD1 subunit homolog A (ARD1A, ARD1, TE2, NAA10)

Function

• in complex with NARG1, displays alpha (N-terminal) acetyltransferase activity
• without NARG1, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation
• cleaved by caspases during apoptosis
• interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, & downregulates it when induced by hypoxia
• interacts with NARG1, NAT13 & with the ribosome

Structure

• belongs to the acetyltransferase family, ARD1 subfamily
• contains 1 N-acetyltransferase domain

Compartment

• cytoplasm, nucleus
• also present in the free cytosolic & cytoskeleton-bound polysomes

Expression

ubiquitous

More general terms

• acetyltransferase
• protein subunit
• phosphoprotein

Additional terms

• GTP-binding protein ARD1; ADP-ribosylation factor domain-containing protein 1; tripartite motif-containing protein 23; RING finger protein 46 (TRIM23, ARD1, ARFD1, RNF46)

Database

• UniProt: http://www.uniprot.org/uniprot/P41227.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8260
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8260
• OMIM: https://mirror.omim.org/entry/300013