NMDA receptor-regulated protein 1; N-alpha-acetyltransferase 15, natA auxiliary subunit; gastric cancer antigen Ga19; N-terminal acetyltransferase; protein tubedown-1; Tbdn100 (NAA15, GA19, NARG1, NATH, TBDN100)

Function

• ARD1-NARG1 complex with acetyltransferase activity
• vascular, hematopoietic & neuronal growth & development
• retinal neovascularisation in adult ocular endothelial cells
• in complex with XRCC6 (G22P1) & XRCC5 (Ku80), up-regulates transcription from osteocalcin promoter
• interacts with XRCC6 (G22P1), XRCC5, ARD1
• cleaved by caspases during apoptosis; results in stable 35 kD fragment

Structure

contains 8 TPR repeats

Compartment

cytoplasmic, nuclear in some cases

Alternative splicing

named isoforms=2

Expression

• expressed at high levels in testis & ocular endothelial cells, brain (corpus callosum), heart, colon, bone marrow
• lower levels in most adult tissues

Pathology

• overexpressed in:
  • gastric cancer
  • papillary thyroid carcinoma
  • Burkitt lymphoma cell line (Daudi cells).
• specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy

More general terms

• nuclear protein
• phosphoprotein
• protein subunit

Additional terms

• NMDA receptor-associated protein 1; NMDA receptor glutamate-binding subunit; MAPK-activating protein PM02 (GRINA, NMDARA1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80155
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80155
• OMIM: https://mirror.omim.org/entry/608000
• UniProt: http://www.uniprot.org/uniprot/Q9BXJ9.html