cytohesin-3; PH, SEC7 & coiled-coil domain-containing protein 3; ARF nucleotide-binding site opener 3; protein ARNO3; general receptor of phosphoinositides 1; Grp1 (CYTH3, ARNO3, GRP1, PSCD3)

Function

• promotes guanine-nucleotide exchange on ARF1
• promotes the activation of ARF through replacement of GDP with GTP
• binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-triphosphate with high affinity
• interacts with GRASP (putative)

Structure

• contains 1 PH domain
• contains 1 SEC7 domain

Alternative splicing

named isoforms=2

Expression

• very low expression liver, thymus & peripheral blood lymphocytes

More general terms

• cytohesin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9265
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9265
• OMIM: https://mirror.omim.org/entry/605081
• UniProt: http://www.uniprot.org/uniprot/O43739.html