cytohesin-2; PH, SEC7 & coiled-coil domain-containing protein 2; ARF nucleotide-binding site opener; protein ARNO; ARF exchange factor (CYTH2 ARNO PSCD2 PSCD2L)

Function

• promotes guanine-nucleotide exchange on ARF1, ARF3 & ARF6
• promotes activation of ARF through replacement of GDP with GTP
• heteromer composed of GRASP, CYTH2 & at least one GRM1 (putative)
• interacts with ARRB1

Structure

• contains 1 PH domain
• contains 1 SEC7 domain

Alternative splicing

named isoforms=2

Expression

ubiquitous

Notes

• ARNO may be cytohesin-2

More general terms

• cytohesin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9266
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9266
• OMIM: https://mirror.omim.org/entry/602488
• UniProt: http://www.uniprot.org/uniprot/Q99418.html